pone.0262173.s004.tif (45.13 MB)
Cellular ARA and ARA/DGLA ratio by genotype at rs174537 and LA dietary exposure.
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posted on 2022-01-20, 18:26 authored by L. Madison Kirk, Charlotte Mae K. Waits, Alexander C. Bashore, Beverly Dosso, Allison K. Meyers, Antonio C. Renaldo, Thomas J. DePalma, Kelli N. Simms, Nathaniel Hauser, Chia-Chi Chuang Key, Charles E. McCall, John S. Parks, Susan Sergeant, Carl D. Langefeld, Aleksander Skardal, Elaheh RahbarExposure to dietary LA did not result in significantly different differences within each genotype. However, TTs consistently exhibited lower (A) ARA and (B) ARA/DGLA levels.
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specifically linoleic acidgenetic variants nearfatty acid desaturasediv >< pdimensional hepatic constructdimensional culture modelsde novo lipogenesisfatty acid metabolismsignificantly reduced fads1reproducibly displayed allelemodern western dietincluding lipid esterificationdriving human diseasespecific metabolic activityslowest metabolic conversionhuman pufa metabolismlipid metabolismsubsequent metabolismminor alleleincluding obesityhuman pufahuman populationsfads1 activitycardiovascular disease>) displayedvivo tt rs174537 results supportrelevant genepoorly replicatemechanistic explorationinflammatory metabolitesinflammatory mediatorsinflammatory diseasesindividuals homozygoushepatocytes derivedhaplotype blockenriched mediae .,dietary omegadiet interactionscurrent twocholesterol efflux3d hydrogels
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