pntd.0009940.s003.tif (852.28 kB)
Cell responsiveness tends to correlate with clinical score.
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posted on 2021-11-12, 18:36 authored by Brenda Rocamonde, Nicolas Futsch, Noemia Orii, Omran Allatif, Augusto Cesar Penalva de Oliveira, Renaud Mahieux, Jorge Casseb, Hélène DutartreCorrelation between IPEC Score of HAM/TSP patients and the frequency of (A) IFNα+ cDC2 and TNFα+ cDC1; and (B) IL-12+ pDC after R848 stimulation. Spearman test was applied to determine the correlation between the two factors.
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tropical spastic paraparesissup >+pdc producing ilcell leukemia virushigher ifnγ responsivenessdevastating neurodegenerative diseasemonocytes producing mipincluding asymptomatic carriersdiv >< ptsp patients comparedtsp blood samplesblood samplesasymptomatic carrierstsp patientstsp comparedhigher frequencydisease occurrencedisease manifestationsteady statesignaling pathwaypotential consequencenk cellsneuroinflammatory statusmechanism underlyinglower responselike receptorinflammatory responseinfected volunteersincreasing numberincreased sensitivityimmune cellseffective treatmentcorticosteroid treatmentsadaptive compartment
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