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Cell-to-cell mtDNA variability for larger mtDNA populations.

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posted on 2023-03-23, 18:27 authored by Robert C. Glastad, Iain G. Johnston

Following Fig 2 in the main text, but for N0 = 1000 mtDNAs rather than N0 = 100. Normalised heteroplasmy variance V′(h) (left column) and copy number variance V(N) (right column) for mtDNA randomly distributed in networks. A: simulations for h = 0.1; B: simulations for h = 0.5; C: sum over state variables for h = 0.5; D: first-order Taylor expansion for h = 0.5. The three columns for each panel give decreasing network heterogeneity, expressed via different seed numbers, 4, 16 and 64 (more seed points give a more homogeneous network). In each panel, variances are given for different values of wild and mutant type network inclusion parameters p (horizontal axis) and q (vertical axis). White baseline reflects the null case from the analytic sum without any network inclusion.