pbio.3001447.s002.tif (1.49 MB)
Cardiac-specific p38γ/δ overexpression induce functional and geometrical changes in both male and female mice.
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posted on 2021-11-10, 18:30 authored by Ayelén M. Santamans, Valle Montalvo-Romeral, Alfonso Mora, Juan Antonio Lopez, Francisco González-Romero, Daniel Jimenez-Blasco, Elena Rodríguez, Aránzazu Pintor-Chocano, Cristina Casanueva-Benítez, Rebeca Acín-Pérez, Luis Leiva-Vega, Jordi Duran, Joan J. Guinovart, Jesús Jiménez-Borreguero, José Antonio Enríquez, María Villlalba-Orero, Juan P. Bolaños, Patricia Aspichueta, Jesús Vázquez, Bárbara González-Terán, Guadalupe SabioEchocardiography analyses of hearts at PD14 from AAV-cTnT-GFP-Luc (TnTGFP; control mice) or TnTp38γ/δact mice (with AAV injection at PD1). Data are mean ± SEM. (n = 6–8). *p < 0.05, **p < 0.01, ***p < 0.001 by Student t test. Raw data are given in S14 Fig. AAV, adeno-associated virus; EF, ejection fraction; FS, fractional shortening; IVS;d, interventricular septum thickness in diastole; LVPW;d, left ventricle posterior wall thickness in diastole.
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p38 &# 948p38 &# 947maladaptive cardiac pathogenesisglycolytic energy productionglycogen synthase 1glycogen metabolism inactivationcardiomyocyte fuel supplycardiac glycogen productionactivated protein kinasesearly metabolic shiftbody metabolic deregulationmaternal diet supplementationfatty acid oxidationpostnatal heart developmentnewborn mice resultsearly gys1 phosphorylationmetabolic changeresults suggestneonate miceinhibitory phosphorylationfatty acidsdiet interventionsxlink ">premature inductionfirst weeksadverse effects
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