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CXCR4 immunohistochemical (IHC) staining.

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posted on 2021-01-28, 18:32 authored by Andrea S. Fung, Karen Kopciuk, Michelle L. Dean, Adrijana D’Silva, Shannon Otsuka, Alexander Klimowicz, Desiree Hao, Don Morris, D. Gwyn Bebb

CXCR4 expression in negative and positive (HeLa) control cells (left panel). CXCR4 staining in early stage non-small cell lung cancer patients, with low (right top panel) and high CXCR4 expression (right bottom panel) shown in red. DAPI nuclear staining shown in blue, and PCK tumor cytosolic component shown in green.

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    lung carcinogenesisMethods Patient characteristicsCXCR 4 groupsmultivariable analysisstudy quantifies CXCR 4 expressionOSHRlung cancer evolutionGlans-Look Lung Cancercytokine receptor CXCR 4stage non-small cell lung cancer pa...PHConclusions CXCR 4 expression increasesTom Baker Cancer Centrestage diseasecytokine receptors increasesresected stage I-III NSCLC patientsgender-specific recurrence-freegender-specific differencesTMAHazard Ratiostage IV patientssurvival outcomesgender differencestage IV non-small cell lung cancerCXCR 4 expressionMedian RFSCXCR 4 expression increasesTBCCSDResults 176 stage I-III NSCLC patientsMSMtissue microarraysstage NSCLC patientslung carcinogenesis warrant54.5 monthsoutcome dataKaplan-Meier analyses80.9 months vsstage progression52.8 months vsG-LLC

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