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CQ/HCQ inhibit tumor growth in ATLL cell xenograft mice.

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posted on 2021-08-18, 17:37 authored by Yanuar Rahmat Fauzi, Shingo Nakahata, Syahrul Chilmi, Tomonaga Ichikawa, Phawut Nueangphuet, Ryoji Yamaguchi, Tatsufumi Nakamura, Kazuya Shimoda, Kazuhiro Morishita

Photograph of a tumor isolated from mice bearing the indicated cell lines after treatment with CQ, HCQ, or water.

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    p 47CQ-treated ATLL cellsp 47 levellupus erythematosusFDAantitumor effectdose-dependent mannerAntitumor effectsNSFL 1CT-cell leukemia virus type 1tumor growthcell growth inhibitionCQ administrationATLL cellsautophagic p 47 degradationsurvival rateNFATLL xenograft mouse modelATLL cell deathATLL cell linesHCQHTLVp 47 degradationpathwayautophagy inhibitorSLEantimalarial drugsimmunodeficient mice

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