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CD14 mediates peptidoglycan–polysaccharide complex (PG-PS)-induced secretion of IL-6 and tumor necrosis factor (TNF)-α

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posted on 31.12.2011, 04:37 by Xiangli Li, Blair U Bradford, Frederick Dalldorf, Sanna M Goyert, Stephen A Stimpson, Ronald G Thurman, Sergei S Makarov

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Taken from "CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan–polysaccharide complexes of Gram-positive bacterial cell walls"

Arthritis Research & Therapy 2004;6(3):R273-R281.

Published online 27 Apr 2004


Copyright © 2004 Li et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

Peritoneal macrophages were stimulated for 4 hours with the indicated concentrations of PG-PS. Concentrations of TNF-α and IL-6 were determined in supernatants by ELISA. Each determination was done in duplicates. TNF-α production by peritoneal macrophages. Data represent means ± standard error of the mean from three independent experiments. IL-6 production by peritoneal macrophages. Data represent mean ± SEM from two independent experiments.