pone.0257783.g003.tif (84.36 kB)
Box whisker plots of mitochondrial enzyme activities in stage 2.
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posted on 2021-10-28, 17:29 authored by Hamid Abudhaise, Jan-Willem Taanman, Peter DeMuylder, Barry Fuller, Brian R. DavidsonThe plots demonstrate the distribution of enzyme activities round the median in each group, shown before and after 4-hr end-ischaemic hypothermic machine perfusion. The change in enzyme activities was not significantly different between preservation groups (p > 0.05). Top and bottom whiskers represent the maximum and minimum values, respectively. Circles represent outliers (1.5 to 3x interquartile range) and diamonds represent extreme outliers (> 3x interquartile range).
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static cold storageischaemia reperfusion injuryinduce oxidative damagehypothermic machine perfusionoxygen delivery efficiency001 ), stabilisedp &# 8804mitochondrial respiratory chainmitochondrial function analysismitochondria likely respond28 minutes comparedlower complex iirespiratory functionmitochondrial parametersmitochondrial dysfunctionhour perfusionconsistently loweroxygen supplemented36 minutes3 minutes003 ),xlink ">used clinicallytime measurementsstudy stagesstudy aimedstage 2stage 1respectively ).preservation periodperfusate oxygenparenchymal poorgan steatosishour preservationhighly susceptibledonor historycomplex iicitrate synthase75 vs73 nmol113 nmol05 ).01 ).
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