Blood perfusion of tumor explants.

a + c + e: Representative perfusion images of tumor explants (a): U87; (c) 17CM98 and (e): D17, subjected to the indicated treatments. Minimal flow = blue; maximal flow = red; see color scale on the right of panel a. Note the greenish ring (“halo”) of angiogenic activity around the tumor grafts. b + d +f: Quantified flux of the tumor vicinity (b): U87; (d): 17CM98 and (f) D17, in response to indicated treatments. Data are means ± SEM, (b) n = 6, (d) n = 5; (f) n = 8. Statistical differences were tested with two-way ANOVA. * = p < 0.05, ** = <0.02. Scale bars = 1mm. AU = arbitrary units.