pcbi.1011252.g005.tif (265.84 kB)
Blood flows from left to right through a single inlet and a single outlet in the forking network.
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posted on 2024-02-16, 18:33 authored by Jakub Köry, Vedang Narain, Bernadette J. Stolz, Jakob Kaeppler, Bostjan Markelc, Ruth J. Muschel, Philip K. Maini, Joe M. Pitt-Francis, Helen M. ByrneLi and Vi denote the length and y-extent of a vessel in generation i, respectively. Note that our implementation of network heterogeneity results in vessels at the top of the network being the thickest in their generation and vessels at the bottom being the thinnest.
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small mean diametersnovel computational modelconsidering network compositionangiogenic sprouts showtumour angiogenesis leadsalso identify casessupport blood flowdiv >< pperfusion increases duepoor blood perfusionoptimal irradiation strategyoptimal strategytumour ’largest increasesidentify tumoursblood perfusionperfusion postperfusion enhancementvivo vascular tumoursvascular networkssynthetic tumoursspatially heterogeneoussilico results indicateregular deploymentoxygen heterogeneitylarge numbersincreased hypoxiaimaging datagood candidatescombination therapiesarchitectural features
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