pone.0297625.g004.tif (266.75 kB)
Binding of each phage clone toward individual serum IgG from 10 NT1 and 10 OHC.
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posted on 2024-03-05, 18:27 authored by Thi-Tuyet Trinh Tran, Thi-Hong Nhung Nguyen, Yves Dauvilliers, Roland Liblau, Xuan-Hung NguyenChosen phages were validated for specificity by indirect ELISA using individual IgG samples purified from OHC (n = 10) and NT1 serum (n = 10). Error bars indicate mean +/- SD, the paired t-test p values has been used to assess statistical significance.
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neurons producing orexinnarcolepsy type 1mediated immunity ratherdifferential binding capacityalso named hypocretinserum immunoglobin gnt1 patient cohortunbiased random peptidespecific antigens targetedohc control groupmer peptides derivednt1 serum iggtargeted methodologiesspecific autoantibodiesvarious peptidesstatistically significantselective lossselected usingrtn4 proteinsprevious studiesorexinergic neuronohcs ).lateral hypothalamushypersomnolence complaintshigh reactivityautoimmune responseautoimmune disease
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