ppat.1009352.s004.tif (2.84 MB)
Binding of anti-spike antibodies to SARS-CoV-2-infected cells in immunofluorescence assay.
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posted on 2021-02-26, 18:43 authored by Kuan-Ying A. Huang, Tiong Kit Tan, Ting-Hua Chen, Chung-Guei Huang, Ruth Harvey, Saira Hussain, Cheng-Pin Chen, Adam Harding, Javier Gilbert-Jaramillo, Xu Liu, Michael Knight, Lisa Schimanski, Shin-Ru Shih, Yi-Chun Lin, Chien-Yu Cheng, Shu-Hsing Cheng, Yhu-Chering Huang, Tzou-Yien Lin, Jia-Tsrong Jan, Che Ma, William James, Rodney S. Daniels, John W. McCauley, Pramila Rijal, Alain R. TownsendRepresentative immunofluorescence staining of anti-RBD, anti-S1 and anti-S2 MAbs are shown as apple-green fluorescence a background of red fluorescing material stained by Evans Blue counterstain. Anti-influenza H3 MAb BS 1A was included as a control. Images were acquired with original magnification 40x, scale bar 20 μm.
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3 weeksantibody responseSARS-CoV -2 infectionACE 2-blocking responsePotent humoral responsesCOVID -19 patientscross-inhibiting clustersneutralising antibodiesplasmablast-derived IgGAnti-RBD MAbsplasmablast responses32 anti-spike MAbsvirus spike glycoproteinACE 2non-competing pairsplasmablast responsememory B cellsanti-non-RBD S 1plasmablast-derived MAbsanti-receptor-binding domainACE 2-blocking anti-RBD antibodies
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