pntd.0011910.s004.tif (1.99 MB)
Babies born to T. cruzi-infected mothers and congenitally infected (Group 1) or not (Group 4) with the parasite show similar kinetics of decay of anti-parasite antibodies.
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posted on 2024-01-18, 18:41 authored by Manuel Abal, Virginia Balouz, Rosana Lopez, M. Eugenia Giorgi, Carla Marino, Cintia V. Cruz, Jaime Altcheh, Carlos A. BuscagliaKaplan-Meier curves showing the survival time for antibodies detected by tELISA (red) and α-Gal-ELISA (green) for patients from Group 1 (dashed lines) and Group 4 (solid lines). Median negativization values are indicated for each data set. Censored cases are indicated with dots. Log-rank (Mantel-Cox) analyses were performed to compare median time of negative seroconversion.
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trypomastigotes surface coattechnical difficulties associatedprotective antibody responseprevious studies indicatedpatient negative seroconversionlinked immunosorbent assayincluded 39 nonbsa scaffold decorated83 months ];3 groups based>- infected mothersretrospective cohort studygal antigenic surrogateelisa may assistvs 60 monthsconventional serological tests>- infected childrentrypanosoma cruzi 4 %), αconventional serological methods3 %) patients>- infectedserological responsesconventional serologyvs 43treated childrenparasitological testscruzi infected infantsinfected individualsgroup 45 months4 years36 months23 months3 years3 daysxlink ">treatment initiationtreatment evaluationtools evaluatedtherapeutic responsestherapeutic markertermed ngpsynthetic αsuccessful treatmentsuboptimal seroprevalencestraightforward postshorten followseveral unitsroutine implementationproper evaluationprolonged persistencep novel toolneoglycoprotein consistingic 95house enzymehigher rateherein developedevery groupdisappears soondiagnostic needsdetailed analysiscontrol cohortchagas diseaseanalyzed separately31 days26 days16 years
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