posted on 2022-10-14, 17:33authored byDanielle Almeida Braggio, Fernanda Costas C. de Faria, David Koller, Feng Jin, Abeba Zewdu, Gonzalo Lopez, Kara Batte, Lucia Casadei, Meng Welliver, Stephen K. Horrigan, Ruolan Han, Jeffrey L. Larson, Anne M. Strohecker, Raphael E. Pollock
Transducin β-like protein 1 (TBL1) recruits β-catenin to the Wnt target gene promoter. BC2059 disrupts the binding of β-catenin to TBL1, facilitating β-catenin destruction, resulting in the inhibition of the Wnt/β-catenin pathway.