pone.0256640.g005.tif (1.11 MB)
BAG and UbL mutants disrupt interaction of Bag-1 with protein quality control network.
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posted on 2021-08-24, 17:29 authored by Nisan Denizce Can, Ezgi Basturk, Tugba Kizilboga, Izzet Mehmet Akcay, Baran Dingiloglu, Ozge Tatli, Sevilay Acar, Pelin Ozfiliz Kilbas, Efe Elbeyli, Serena Muratcioglu, Ayse Tarbin Jannuzzi, Attila Gursoy, Ozlem Keskin, Hamdi Levent Doganay, Betul Karademir Yilmaz, Gizem Dinler DoganayProtein abundances in the interactomes of TAP–Bag-1S mutants are compared to that of wild-type TAP–Bag-1S. Fold changes are depicted in log2 base for a. R161D, b. R162E, c. R193D, and d. I103K mutants.
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ERADproteasome componentsER-associated protein degradationinteraction mapprotein homeostasisER ATPaseNovel interaction partnersmass spectrometry-based proteomicshotspot residuesMCF -7 cellsRad 23Bdegradation pathwaysprotein processingER-resident proteinssubcellular localizationsubiquitinated proteinssilico predictionsnovel interaction partnersisoformprotein quality control elementsmultifunctional proteininteraction networkproteasomal activityinteraction surfacesInteractome analysisBag -1. Mutationsbreast cancer patientsnon-overlapping functionsCD 147 glycosylation patternHsp 70 chaperone activityVCPendoplasmic reticulum-associated de...
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