pone.0256980.g007.tif (215.14 kB)
Antibody responses by IFA to PfNF54 sporozoites and Pf3D7 blood stages.
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posted on 2021-09-08, 17:25 authored by Marvin J. Sklar, Santina Maiolatesi, Noelle Patterson, Martha Sedegah, Keith Limbach, Nimfa Teneza-Mora, Ilin Chuang, K. Monique Hollis-Perry, Jo Glenna Banania, Ivelese Guzman, Harini Ganeshan, Sharina Reyes, Michael R. Hollingdale, Mimi Wong, Ashley Lindstrom, Anatalio Reyes, Yolanda Alcorta, Lindsey Garver, Kelli Bankard, Arnel Belmonte, Maria Belmonte, Jun Huang, Kalpana Gowda, Sandra Inoue, Rachel Velasco, Elke Bergmann-Leitner, Jack Hutter, Tida Lee, Nehkonti Adams, Sidhartha Chaudhury, Devin Hunt, Cindy Tamminga, Eleanor Berrie, Duncan Bellamy, Mustapha Bittaye, Katie Ewer, Carter Diggs, Lorraine A. Soisson, Alison Lawrie, Adrian Hill, Thomas L. Richie, Eileen Villasante, Judith E. Epstein, Christopher A. DuplessisThe box plots represent responses to PfNF54 sporozoites and Pf3D7 blood stages. Responses of protected subjects are color-coded; not protected (NP) subjects are open circles.
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thick blood smearsplasmodium falciparum mosquito bite usinglog rank testifn -&# 947systemic adverse eventsrelated adhesive proteinmalaria multiple epitopeshigh level pre7 days ).erythrocytic stage antigendays post chmichimpanzee adenovirus 630 days ).systemic aes comparedboost vaccine encodingthird precircumsporozoite proteinadverse effect0229 ).xlink ">vaccine efficacythird antigensignificantly highersignificance calculatedrisk ratiopf3d7 strainopen labelmean 13mean 12infectivity controlsincreased frequenciesifa responseshealthy malariafour weeksfluorospot responsesexisting immunityelisa antibodiesconfirmed protectioncellular responsescell responsesantigen regimenachieve increased27 %)
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