ppat.1011805.g005.tif (876.73 kB)
Antibody neutralization activity after challenge.
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posted on 2024-01-10, 18:34 authored by Juan García-Bernalt Diego, Gagandeep Singh, Sonia Jangra, Kim Handrejk, Manon Laporte, Lauren A. Chang, Sara S. El Zahed, Lars Pache, Max W. Chang, Prajakta Warang, Sadaf Aslam, Ignacio Mena, Brett T. Webb, Christopher Benner, Adolfo García-Sastre, Michael Schotsaert(A) Micro-neutralization assays performed in the presence of 350 TCID50 per well of virus and sera collected 5 DPI. In all cases, the left panel represents neutralization activity against USA-WA1/2020 (clear: unvaccinated; solid: vaccinated) and the right panel neutralization activity against the variant of infection (clear: unvaccinated; solid: vaccinated). Statistical analysis: n = 5/group; Mann-Whitney U test. (B) Antigenic map constructed with ID50 values of unvaccinated animals. Each square in the grid represents one antigenic distance unit (C) Antigenic map constructed with ID50 values of BNT162b2 primed animals. Each square in the grid represents one antigenic distance unit.
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hybrid immunity resultedbroadly reactive bvaccination reduced morbidityallowed breakthrough infectionsbreakthrough infectionsreactive seravaccination statusvaccination primedvaccinated hamsterstranscriptomics postneutralizing antibodiesinterstitial macrophageshigh titersdisease coursechallenged hamsterscell responsesancestral virusancestral spike
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