Anti-IL-10R blockade partially restores the ability of bacterial control in Bhlhe40-deficient mice.

WT, Bhlhe40^-/- and Il10^-/- mice were infected intravaginally with 1×10⁵ C. muridarum. Cohorts of WT and Bhlhe40^-/- mice were treated with anti-IL-10R or isotype control antibody twice a week until day 21. Bacterial shedding from the lower FRT were monitored by vaginal swabs. Data are results from two independent experiments with 7–8 mice per group. Each data point represents an individual mouse. Error bars represent the mean ± SEM. ****p < 0.0001 by one-way ANOVA and *p < 0.05, **p < 0.01, ***p < 0.001 by ANOVA multiple comparisons.