Anti-CD4 antibody treatment does not induce T cell activation in the tissues of ART-suppressed, HIV-infected humanized mice following CD4⁺ T cell reconstitution.

The frequency of activated (CD38⁺HLA-DR⁺) CD4⁺ (A) and CD8⁺ (B) T cells was determined by flow cytometry at necropsy. BM, bone marrow; LIV, liver; LNG, lung; LN, lymph nodes; SPL, spleen, ORG, human thymic organoid. Combined: all individual tissues from all animals are graphed together. Anti-CD4 antibody treated animals (n = 6) are shown in red; control animals (n = 4) are shown in black. Data are expressed as mean ± SEM. Statistical analyses were performed using unpaired two-sided Mann–Whitney U-tests. Statistical significance was considered when P < 0.05.

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