ppat.1011824.s001.tif (247.43 kB)
Anti-CD4 antibody treatment does not induce T cell activation in blood.
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posted on 2023-12-06, 18:26 authored by Lijun Ling, Chandrav De, Rae Ann Spagnuolo, Nurjahan Begum, Shane D. Falcinelli, Nancie M. Archin, Martina Kovarova, Guido Silvestri, Angela Wahl, David M. Margolis, J. Victor GarciaThe frequency of activated (CD38+HLA-DR+) CD4+ (A) and CD8+ (B) T cells in the peripheral blood was longitudinally determined by flow cytometry. Blue arrows in A and B show the timing of 4 anti-CD4 antibody administrations to anti-CD4 antibody treated animals. Anti-CD4 antibody treated animals (n = 6) are shown in red; control animals (n = 4) are shown in black. Data are expressed as mean ± SEM. Statistical analyses were performed using unpaired two-sided Mann–Whitney U-tests. Statistical significance was considered when P < 0.05.
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sup >+standing clinical interventionlung 26 daysdiv >< pcurrently available approachescurrent antiretroviral therapyacceptable safety profileassociated viral rnaeradicate hiv infectionlatently infected cellstreated animals comparedsuppressed animals resultstissues analyzed exceptsignificantly lower levelslatent hiv reservoirsuppressive art reduceshiv infected artperipheral blood cellscell recovery comparedcd4 antibody treatmenttreated animalsperipheral bloodhiv reservoirsuppressive artviral reboundresults suggestlifelong treatmentantibody treatmentuninfected cellstransient cd4substantial reductionspeople livingmediated cd4humanized micefold reductionessentially indistinguishablecell recoverycell depletioncd4 antibody
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