pntd.0009602.s006.tif (922.4 kB)
Analysis of combinations of compound 1 with 50 μM BNZ.
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posted on 2021-07-16, 17:44 authored by Juan Cantizani, Pablo Gamallo, Ignacio Cotillo, Raquel Alvarez-Velilla, Julio MartinAverage of T. cruzi amastigotes per cell was plotted in Y axis and bars were coloured by concentration of compound 1 (50 μM in yellow, 16.67 μM in red and no compound in blue). 50 μM BNZ was present in all the cases. Two time-points were represented, i.e. 4 and 24 hours.
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curve descriptorsAutomated data reductioncompounds collectionBNZGSK 1.8animal modelsCurrent chemotherapeuticsLatin Americacompound optimisation programsNIFscreening campaigndata analysismigration flowsPCAnitroaromatic compoundssuboptimal efficacycompound setsGSK Chagas Box Chagas diseasedrug discovererscombo therapyantifungal azolesefficacy outcomesHTS campaignChagas disease drug discoveryguide navigationshow efficacycompound selectionTrypanosoma cruzihigh-throughput compoundCYPbench modelsGSK Chagas Box
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