Fig 4.tif (962.32 kB)
Albuminoid genomic region.
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posted on 2017-09-18, 17:33 authored by Rance Nault, Kelly A. Fader, Jack R. Harkema, Tim ZacharewskiAlbuminoid genomic region including Alb, Afp, and Afm. UCSC genome browser tracks show (1) the scale, (2) male AhR ChIP-seq peaks at 2 h, (3) male AhR enriched sites (FDR ≤ 0.05), (4) female AhR ChIP-seq peaks, (5) female AhR enriched sites (FDR ≤ 0.05), (6) location of pDREs (diagonal line indicates pDREs with a matrix similarity score ≥0.85), and (7) location of Alb, Afp and Afm genes within the albuminoid genomic region. Gc, the fourth albuminoid, is located 1 Mb upstream of Alb (not shown). Tracks are available for visualization at http://dbzach.fst.msu.edu/index.php/publications/supplementary-data/.
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cell-specific responsesAhR activation causesmale-biased Gstp 1TCDDRNA-seq dataaryl hydrocarbon receptor92 daysAttenuated liver-specificHnf 6mice gavagedBcl 6Dose-dependent effectsGHR-JAK 2-STATCUX 2-mediated transcriptionZhx 2Hnf 4aaryl hydrocarbon receptor activationAhR enrichmentLiver-specific genes2 hrprotein leveldimorphic gene expressionDisrupted regulation4 daysStat 5bC 57BL micetranscription factortranscriptional regulatorsdimorphic expression181 genes
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