pone.0297803.g003.tif (1.09 MB)

Agarose gel electrophoresis of GAG extract from Rapana venosa marine snail before and after incubation with heparinase III (Hep III) and chondroitinase ABC (Chase ABC).

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posted on 2024-02-15, 18:42 authored by Alexandra Gaspar-Pintiliescu, Laura M. Stefan, Elena Mihai, Catalina Sanda, Vasile S. Manoiu, Daniela Berger, Oana Craciunescu

Standards of bovine condroitin sulfate (CS) and heparan sulfate (HS) migrated in similar conditions.

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novel bioactive compound inhibit cell proliferation important pharmacological applications free radical scavenging fourier transform infrared div >< p dead assays showed agarose gel electrophoresis 2 cell cultures tumoral cell migration heparinase iii indicated rapana venosa bovine heparan sulfate high antioxidant activity venosa heparan sulfate spectra indicated antioxidant activity vitro sulfate content r extract migration chondroitin sulfate unique molecules sulfation ratio specific digestion slightly decreased scarce information potential use marine snail marine glycosaminoglycans main component human hep enzymatic treatment enzymatic digestion elemental composition different invertebrates cytocompatible concentrations chondroitinase abc capacity decreased biomedical use antiproliferative properties antiproliferative effect antiproliferative activities also inhibited

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