Adiponectin haplotype association analysis at ADIPOQ in the 9,262 participants from the METSIM study.
A) Haplotype of all adiponectin-increasing alleles used as the baseline reference. B) Haplotype with the largest sample size used as the baseline reference (same as the baseline reference haplotype used in S10 Fig). Haplotypes with the same allele for any given signal (e.g. signal ‘A’) show different effect sizes (betas) consistent with their single variant results for alleles at the other signals (e.g. B, C, etc). Haplotypes were constructed with the lead variant of each association signal using HaploStats. ‘Count’ indicates the number of estimated haplotypes. Alleles associated with lower adiponectin are shown in purple while alleles associated with higher adiponectin are shown in green. Haplotype association was performed with adiponectin inverse normalized residuals after adjusting for age, age2, and BMI using the haplotype containing the adiponectin-increasing alleles at all seven signals as the reference. The dashed line divides common haplotypes from rare (haplotype frequency <0.001.
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