10194_2024_1714_MOESM1_ESM.tif (119.34 MB)

Additional file 1 of The crucial role of locus coeruleus noradrenergic neurons in the interaction between acute sleep disturbance and headache

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posted on 2024-03-06, 04:41 authored by Bozhi Li, Ya Cao, Huijuan Yuan, Zhe Yu, Shuai Miao, Chunxiao Yang, Zihua Gong, Wei Xie, Chenhao Li, Wenhao Bai, Wenjing Tang, Dengfa Zhao, Shengyuan Yu

Additional file 1: A Schematic depiction of the timeline demonstrating the aggravating influence of ASD on NTG-induced behavioral changes (VEH, n = 12 mice; ASD, n = 12 mice; NTG, n = 12 mice; NTG+ASD, n = 12 mice). B, C and D Graphical representations of B, C and D demonstrate behavioral statistical trends recorded at the 26-hour time point within the timeline (1.5 to 2 hours post NTG injection). E and F In mice given intraperitoneal injections of NTG at 1-week intervals, there were no statistically significant changes in the periorbital (E) or paw (F) threshold.

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the National Natural Science Foundation of China the National Key Research and Development Program of China the Logistics Support Research Project of China

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primarily employed nitroglycerin approach enabled us additional investigations demonstrated sleep disturbances share related sleep disturbance increased sleep latency headache pathways intersect headache abstract background facilitating headache triggered acute sleep disturbance acute sleep deprivation intensified pain facilitation induced headache facilitation asd enhances headache lc noradrenergic neurons pain facilitation acute headache noradrenergic neurons sleep quality like headache headache threshold although headache neurons reduced induced migraine induced activation study focused significant anatomical separate roles primary sites opposite effect mechanism underlying locus coeruleus lc serves lc reduced lc ),intricate nature functional region findings indicate conducted experiments clinical studies chemogenetic manipulation better understand asd facilitated anatomical foundations

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