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Additional file 1 of Pericytes are protective in experimental pneumococcal meningitis through regulating leukocyte infiltration and blood–brain barrier function
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posted on 2023-11-18, 05:40 authored by Nina C. Teske, Susanne Dyckhoff-Shen, Paul Beckenbauer, Jan Philipp Bewersdorf, Joo-Yeon Engelen-Lee, Sven Hammerschmidt, Roland E. Kälin, Hans-Walter Pfister, Matthijs C. Brouwer, Matthias Klein, Rainer Glass, Diederik van de Beek, Uwe KoedelAdditional file 1: Figure S1. Interleukin (IL)-6 and lactate dehydrogenase (LDH) release from human (green and orange bars) and murine (blue and red bars) primary brain pericytes after exposure to increasing concentrations (MOI = 2.5, 10, 40, 160) of the pneumococcal serotypes 7F (7F), 6B (6B), 2 (D39), as well as a pneumolysin-deficient isogenic D39 mutant (D39ΔPLY). Data from serotype 2 (grey bars) are also shown in Fig. 1. Data are given as individual values as well as means ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, using ANOVA with Tukey’s multiple comparisons test.
