pone.0292091.g006.tif (207.36 kB)
Acute phosphate uptake in rats treated with a fixed, 1.2 mg/kg dose of LY3358966 and increasing doses of LY3304000.
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posted on 2024-01-26, 18:40 authored by Xiaojun Wang, Xiaohong Yu, Kostas Gavardinas, Asim Dey, Hong Y. Zhang, Gina Porter, Leah Porras, Lan Yu, Haihong Guo, Charles A. Reidy, Joseph V. Haas, Yanping Xu, Mark C. Kowala, Prabhakar K. Jadhav, John R. WetterauAcute phosphate uptake in rats treated with a fixed, 1.2 mg/kg dose of LY3358966 and increasing doses of LY3304000.
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xlink "> manytwo opposing effectsrelatively low levelscurrent therapies focusedchronic kidney diseasecell surface phanimal model dominatedly3304000 modestly inhibitedintestine demonstrated ly3304000serum phosphate levelsly3358966 synergistically inhibitednhe3 ), ly3304000intestinal phosphate absorptiongastrointestinal phosphate absorptionnpt2b ), ly3358966phosphate absorptionradiolabeled phosphatephosphate uptakenhe3 inhibitortreat hyperphosphatemiastudies measuringpathological consequencesnpt2b pathwaynhe3 inhibitioninhibits paracellularhigher phsdiffusional uptakeacute uptakeactive transporter
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