Accuracy of information-metabolic efficiency approximation.

To calculate the capacity-cost functions, we calculated the mutual information using Eq (5) with the input probability distribution calculated from Eqs (12) and (14). Here we compare the information-metabolic efficiencies calculated with the approximation and the Jimbo-Kunisawa algorithm. A: The same contour plot as in Fig 5B with information-metabolic efficiencies calculated with the Jimbo-Kunisawa algorithm. B: Information-metabolic efficiencies calculated with the Fisher-information-based input distribution. C: Heatmap of the relative differences. Note that the approximation can only reach values lower than the actual information-metabolic efficiency.

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