pone.0261783.g004.tif (926.98 kB)
Accessibility changes in genes after VSG in inguinal mature adipocytes.
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posted on 2021-12-31, 18:43 authored by Blaine Harlan, Hui Gyu Park, Roman Spektor, Bethany Cummings, J. Thomas Brenna, Paul D. SolowayA. Volcano plot of differentially accessible genes comparing VSG to SHAM ING adipocytes. Positive fold change indicates increased accessibility in VSG cells. B. Biological process gene ontology enrichment for the top 200 most significantly differentially accessible genes. C. Volcano plots of differentially accessible genes in VSG vs SHAM in each mature adipocyte cluster.
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vertical sleeve gastrectomyterm weight lossreceived sham surgeryprecede weight lossfatty acid desaturasedependent metabolic shiftcell atac sequencingtreat obesity resultingspecific cellular compositionchromatin accessibility patternscell chromatin accessibilitydiv >< pepididymal adipose depotsepididymal depotsspecific reductionattenuate obesityadipose playssubstantially reducedreduced accumulationobserved depotmechanisms underlyingmature adipocyteslipid profilinginsulin resistancehealth improvementsenergy homeostasiscrucial rolecardiometabolic pathologiesbeneficial effectsadipocytes induced
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