ppat.1011805.g008.tif (932.04 kB)
Abundance of different cell subsets in the lungs of infected hamsters extrapolated from the host transcriptome.
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posted on 2024-01-10, 18:34 authored by Juan García-Bernalt Diego, Gagandeep Singh, Sonia Jangra, Kim Handrejk, Manon Laporte, Lauren A. Chang, Sara S. El Zahed, Lars Pache, Max W. Chang, Prajakta Warang, Sadaf Aslam, Ignacio Mena, Brett T. Webb, Christopher Benner, Adolfo García-Sastre, Michael SchotsaertRNA was extracted from lungs of infected hamsters at 5 DPI and subjected to bulk RNA-seq analysis. Host transcriptomes were used to impute gene expression profiles using the Cibersortx algorithm. Statistical analysis: n = 5/group; Mann-Whitney U test.
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hybrid immunity resultedbroadly reactive bvaccination reduced morbidityallowed breakthrough infectionsbreakthrough infectionsreactive seravaccination statusvaccination primedvaccinated hamsterstranscriptomics postneutralizing antibodiesinterstitial macrophageshigh titersdisease coursechallenged hamsterscell responsesancestral virusancestral spike
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