pone.0294465.g006.tif (297.39 kB)
Aβ oligomers that bind to PrPC are present in APP-PS1 at higher levels than in J20 mouse brain, but do not change due PrPC expression.
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posted on 2023-11-17, 18:40 authored by Silvia A. Purro, Michael Farmer, Elizabeth Noble, Claire J. Sarell, Megan Powell, Daniel Yip, Lauren Giggins, Leila Zakka, David X. Thomas, Mark Farrow, Andrew J. Nicoll, Dominic Walsh, John CollingeTotal brain homogenates were analysed by DELFIA immunoassay to detect PrPC-binding Aβ species (APP-PS1 vs J20, p = 0.037; WT vs APP-PS1, p = 0.009; APP-PS1 vs APP-PS1 PrPC KO, p>0.99; WT vs J20, p = 0.12; J20 vs J20 PrPC KO, p>0.99). n = 6–9.
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two mouse modelstoxic cascade elicitedlongitudinal study assessingcurrent mouse modelsj20 mouse linecommonly used j20ps1 mouse modelsoligomer profiles unalteredgiven mouse modelyielded contradictory resultsdifferent mouse modelsaβ toxicity mediateddiv >< pcellular prion proteinalzheimer &# 8217c disease accumulate amyloidaβ oligomers concomitantlydifferent modelj20 micevitro ps1 miceoligomer productionalzheimer ’&# 946amyloid βamyloid accumulationresults suggestresults provideresults obtaineddifferent targetsdifferent ratesaβ oligomersregister fibrilsoligomers formedlower levelhistological featureshigher levelsfully mimicestablished receptordistinguishes parallelcould bindcomplex diseaseclinical diseaseanalysis demonstratedalways reproducedad failad ).
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