pone.0292243.g002.tif (711.18 kB)
A heat map was generated for all the miRs utilized in the array, as a function of a fold change from referent control values.
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posted on 2024-02-02, 18:31 authored by Stephanie L. Samani, Shayne C. Barlow, Lisa A. Freeburg, Traci L. Jones, Marlee Poole, Mark A. Sarzynski, Michael R. Zile, Tarek Shazly, Francis G. SpinaleThe rows represent individual pig values following the exercise protocol. A number of miRs changed as a function of exercise within the LV myocardium and were selected for further analysis as indicated in Table 2.
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weight matched nonunique findings setspeckle tracking echocardiographyregulating pathways relevantr &# 8805localized inflammatory processlocal inflammatory pathwaysidentify underlying mechanismscalcium handling processesmyocardial relaxation processestranscriptional molecular pathwaysregional myocardial stiffness10 degrees elevationparticularly diastolic function84 mir arraymyocardial mir profilinglv myocardial structurespecific mirs responsibleexercise causes changes)3 mrna occurredleft ventricle functionlv myocardial stiffnesspigs myocardial stiffnesstranscriptional eventsleft ventricular10 minxlink ">project testedpoorly understoodmirs ))following exercisefold decreaseexercise trainingexercise pigsdirectly associateddirect effectschanged mirscentral hypothesisapproximately 505 p5 mph5 days25 kg
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