pgen.1010582.s005.tif (2.28 MB)
AMPK and histone acetyltransferases Elp3, Hat1, Rtt109 and Mst2 have limited effect on stress gene derepression in cbf11Δ cells.
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posted on 2023-01-10, 18:29 authored by Jarmila Princová, Clàudia Salat-Canela, Petr Daněk, Anna Marešová, Laura de Cubas, Jürg Bähler, José Ayté, Elena Hidalgo, Martin Převorovský(A,B,C) Expression of the indicated stress genes in cells growing in YES medium was analyzed by RT-qPCR. Mean and SD values of three independent replicates are shown. One-sided Mann-Whitney U test was used to determine statistical significance.
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main pathway respondingcorresponding gene promotersmst1 histone acetyltransferasesschizosaccharomyces pombe pap1 transcription factorshow increased expressionlocalized chromatin hyperacetylationdiv >< presponse gene expressionincreased cellular resistanceatf1 transcription factorconserved sty1 stressgene expressionincreased stressincreased acetylationhistone h3response mechanismsresponse genesregulating transcriptionmga2 cut6 cbf11 specific stresspsychiatric disordersperturbed fattyoxidative stressneurodegenerative diseasesmetabolic statelysine 9lipid metabolismgenes viafission yeastfas inhibitionepigenetic informationdirectly controlcertain metabolitesbecoming apparentalso operateacid metabolismacc /<
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