AHR and PLK1 are important for LUAD progression.

A, Comparison of AHR and PLK1 expressions among normal lung, LUAD, LUSC, and SCLC cell lines using data from the DepMap database. Statistical methods: Welch’s ANOVA test following multiple comparisons (AHR); one-way ANOVA following multiple comparisons (PLK1). B, Kaplan-Meier overall survival curve of 79 SCLC patients from shared dataset (George et al.). Patients are separated into four groups: H-PLK1/H-AHR (PLK1/AHR > median), H-PLK1/L-AHR (PLK1 > median/AHR < median), L-PLK1/H-AHR (PLK1 < median/AHR > median), L-PLK1/L-AHR (PLK1/AHR < median). Statistical method: Log-rank test. C, Kaplan-Meier survival curves of TCGA-LUSC patients separated into four groups: H-PLK1/H-AHR (PLK1/AHR > median), H-PLK1/L-AHR (PLK1 > median/AHR < median), L-PLK1/H-AHR (PLK1 < median/AHR > median), L-PLK1/L-AHR (PLK1/AHR < median). Statistical method: Log-rank test. D, Comparison of AHR and PLK1 expressions (RSEM) between TCGA-LUAD and TCGA-LUSC patients. Statistical method: two-tailed unpaired Welch’s t test. E, Kaplan-Meier survival curves of TCGA-LUAD and TCGA-LUSC patients after adjusting thresholds. In both datasets, thresholds are set as the median expression (RSEM) of PLK1 in TCGA-LUSC and median expression (RSEM) of AHR in TCGA-LUAD. Adjusted thresholds different from previous results are marked with asterisks (H-PLK1* and L-PLK1* in TCGA-LUAD, H-AHR* and L-AHR* in TCGA-LUSC). Statistical method: Log-rank test.

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