pone.0280112.g004.tif (752.28 kB)
AGE-RAGE signaling pathway in diabetic complications.
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posted on 2023-01-04, 18:25 authored by Yangyang Wang, Guoxiu Zu, Ying Yu, Jiqin Tang, Tao Han, Chengdong ZhangAGE-RAGE signaling pathway in diabetic complications.
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target &# 8211protein complex couldprotein &# 8211numerous biological processesmany beneficial effectsmajor global causesirreversible neurological damagecomponent &# 8211blood clots blockrage signaling pathwayp53 signaling pathwayprotein interaction networkincluding oxidative stress97 intersection targetscurcumin &# 8217curcumin &# 8211whose results indicatedgo enrichment analysesfive key targets234 potential targetspotential targetskey targetscore pathwaynetwork pharmacologyintersecting targetsincluding neuroprotectiveusing curcuminsystematically investigatestudy aimedstable staterelated genesmolecular mechanismsmolecular dynamicsmolecular dockinglargest degreeischemic strokeintermolecular affinitiesgained attentiondocking findingscurrently limitedclinical settingsbrain tissuebinding conformationalso constructed
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