4-PBA attenuates pulmonary arterial remodeling.

Lung histology examples from the NORMAL group (A), PAH group (B), REV group (C) and PRE group (D) are shown. In the NORMAL group, the thickness of the pulmonary arterioles was normal and the distribution of smooth muscle cells was even. There was no congestion in the lumen of the pulmonary artery. In the PAH group, significantly increased pulmonary arterial wall thickness, luminal congestion, interstitial lung hemorrhage and increased inflammatory cell infiltration were observed, (marked by arrows). In the REV group, the MCT-induced pulmonary arterial wall thickening and inflammatory cell infiltration were significantly attenuated by 4-PBA. In the PRE group, compared with the PAH group, significantly decreased pulmonary arterial wall thickness, no luminal congestion, and less inflammatory cell infiltration were observed. Scale bars = 50 μm.