pone.0257098.s010.tif (811.33 kB)
2DIR contour plots for data shown in Fig 4.
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posted on 2021-09-14, 17:23 authored by Ariel M. Alperstein, Kathleen S. Molnar, Sidney S. Dicke, Kieran M. Farrell, Leah N. Makley, Martin T. Zanni, Usha P. Andley(A) Contour plot for juvenile human lens data (yellow). (B) Contour plot for age-related cataract human lens data (purple).
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measure uv radiationdiv >< pdeveloping pharmacological treatmentscross peak frequencyalso widely distributedordered secondary structurelike secondary structurecross peak changesmutant mouse lensesrelated cataract diseaseprotein structural relevancediagonal peak frequenciesform amorphous aggregates>- r120g knockwt mouse lensesmouse lens modelhuman hereditary cataractsdimensional infrared spectroscopyhuman lensesdimensional infraredmouse modelporcine lensesocular lenslike fibrilsinduced changeshighly orderedhereditary cataracts>- r120gcrystallin aggregatesvitro tissues throughoutstudy ageneurodegenerative diseasesheterooligomeric complexgeneral agecryab chaperone activityarginine 120alzheimer ’aggregated proteins
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