pone.0257098.s004.tif (2.29 MB)
2DIR contour plots for data shown in Fig 2.
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posted on 2021-09-14, 17:23 authored by Ariel M. Alperstein, Kathleen S. Molnar, Sidney S. Dicke, Kieran M. Farrell, Leah N. Makley, Martin T. Zanni, Usha P. Andley(A) Contour plot for room temperature αB-crystallin (solid light blue). (B) Contour plot for heated αB-crystallin (dashed light blue). (C) Contour plot for room temperature αB-R120G-crystallin (solid maroon). (D) Contour plot for heated αB-R120G-crystallin (dashed maroon).
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measure uv radiationdiv >< pdeveloping pharmacological treatmentscross peak frequencyalso widely distributedordered secondary structurelike secondary structurecross peak changesmutant mouse lensesrelated cataract diseaseprotein structural relevancediagonal peak frequenciesform amorphous aggregates>- r120g knockwt mouse lensesmouse lens modelhuman hereditary cataractsdimensional infrared spectroscopyhuman lensesdimensional infraredmouse modelporcine lensesocular lenslike fibrilsinduced changeshighly orderedhereditary cataracts>- r120gcrystallin aggregatesvitro tissues throughoutstudy ageneurodegenerative diseasesheterooligomeric complexgeneral agecryab chaperone activityarginine 120alzheimer ’aggregated proteins
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