Genotype and allele frequency of rs738409 among individuals with traits related to the metabolic syndrome in Inter99.

The table presents a case-control study of the association of the rs738409 with the metabolic syndrome. It includes 5,847 individuals from the Inter99 cohort. Individuals may have more than one trait. The metabolic syndrome was defined according to the 1999 WHO criteria. Control individuals (n = 1,691) were defined as not having any of the components comprised in the WHO-defined criteria of the metabolic syndrome. Case-individuals with IGR were defined as mentioned in the main text. Individuals with a HOMA-IR value in the highest quartile of the population distribution were defined as having insulin resistance (n = 1,497). Cases with dyslipidemia (n = 1,526) were defined as having serum TAG >1.7 mM and/or HDL-cholesterol <0.9 mM for men and <1 mM for women or treated with lipid-lowering agents. Cases with hypertension (n = 2,383) were defined as having a systolic blood pressure above 140 mmHg and/or diastolic blood pressure above 90 mmHg or treated with antihypertensive medication. Obese cases (n = 2,637) were defined either by a BMI above 30 kg/m² or a waist-to-hip ratio above 0.9 for men and above 0.85 for women. Cases with albuminuria (n = 170) were defined as having an albumin/creatinine ratio above 30 mg/g. Values are means ± SD. Traits were defined as according to the 1999 WHO-defined metabolic syndrome components. Individuals may have more than one trait. P-values were adjusted for age, sex and BMI.