pmed.1003679.s014.xlsx (16.83 kB)

Two-sample Mendelian randomisation estimates of combined-sex instruments for BMI, WHR, and WHRadjBMI effects on female reproductive conditions.

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posted on 2022-02-01, 18:22 authored by Samvida S. Venkatesh, Teresa Ferreira, Stefania Benonisdottir, Nilufer Rahmioglu, Christian M. Becker, Ingrid Granne, Krina T. Zondervan, Michael V. Holmes, Cecilia M. Lindgren, Laura B. L. Wittemans

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wide association studies sup >&# 8722 shared genetic components publicly available genome heavy menstrual bleeding generalised additive models diagnostic anthropometric traits 98 – 4 female reproductive conditions 65 × 10 24 × 10 0130 ), pcos 16 – 1 06 – 1 02 – 1 body mass index reproductive disease data 87 per 1 increased hip circumference higher genetic risk 06 – 2 uf ), pcos bmi ), waist 08 – 1 predicted vat mass xlink "> obesity per 1 xlink ">10 ).whr ),increased risks hip ratio disease prevention reproductive disorders hmb ),whr adjusted uterine fibroids uk biobank sd increase scale genetics results suggest odds ratios obesity trait metabolic hormones mendelian randomisation low prevalence logistic regression little information kg increase insulin resistance identify targets heterogenous extents gynaecological health gwass ).fasting insulin european ancestry estimate observational common indices central obesity causal associations based analysis altered risk aetiological relationships 79 ],64 ],23 ],193 women

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