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The efficacy of Life Review Therapy combined with Memory Specificity Training (LRT-MST) targeting cancer patients in palliative Care: a Randomized Controlled Trial

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Version 2 2017-11-30, 22:15
Version 1 2017-11-24, 21:09
posted on 2017-11-30, 22:15 authored by Gitta KleijnGitta Kleijn, Birgit I. Lissenberg-Witte, Ernst T. Bohlmeijer, Bas Steunenberg, Kitty Knipscheer-Kuijpers, Vincent Willemsen, Annemarie Becker, Egbert F. Smit, Corien M. Eeltink, Anne M.E. Bruynzeel, Maurice van der Vorst, Remco de Bree, C. René Leemans, Michiel W.M. van den Brekel, Pim Cuijpers, Irma Verdonck-de Leeuw

The aim of this study was to evaluate the efficacy of an intervention combining Life Review Therapy (LRT) and Memory Specificity Training (MST) (LRT-MST) to improve ego-integrity and despair among cancer patients in palliative care.

In this multicentre randomized controlled trial, cancer patients in palliative care were randomized to the intervention group (LRT-MST; n=55) or waiting-list control group (n=52). LRT-MST is a 4-session home-based psychological intervention that aims to retrieve specific positive memories, to re-evaluate life events and to reconstruct the story of a patient’s life, including the diagnosis of incurable cancer. Outcome measures were ego-integrity and despair (NEIS), psychological distress, anxiety and depression (HADS), quality of life (EORTC QLQ-C15-PAL), and specificity of the autobiographical memory (AMT). NEIS, HADS and EORTC QLQ-C15-PAL were assessed at baseline (T0), 1 month later (post-treatment; T1), and at 1 month follow-up (T2). AMT was assessed at T0 and T1.


The Netherlands organisation for Health research and Development (ZonMw)