pgen.1009736.s005.xlsx (88.24 kB)
Tabulated summary of the results of the GWAS meta-analysis and RNAi screen.
dataset
posted on 2021-09-07, 17:41 authored by Wenfan Ke, Jordan N. Reed, Chenyu Yang, Noel Higgason, Leila Rayyan, Carolina Wählby, Anne E. Carpenter, Mete Civelek, Eyleen J. O’RourkeList of the 340 human genes associated with obesity traits extracted from 3 previous publications: 1) Mete Civelek, et. al, Am J Hum Genet., 2017 [56]; 2) Masato Akiyama, et.al, Nature Genetics, 2017 [57]; and 3) Audrey Chu, et.al, Nature Genetics, 2017 [58]. 207 of these human genes had C. elegans orthologs. Since there is often more than one C. elegans ortholog per human gene, 386 C. elegans orthologs were actually identified to correspond to the 207 human genes. However, only 293 C. elegans genes were screened because there weren’t available RNAi clones for 96 of the C, elegans orthologs. 14 obese, 2 generic lean, and 3 DIO-suppressor genes were identified and validated.
(XLSX)
History
Usage metrics
Categories
Keywords
identifying pharmacological targetsfar merely correlatedectopic fat depotsdiv >< passociated metabolic syndromemodel systems compatiblereport 14 genescandidate genes reportedobesity across phylogenywide association studiescausal obesity genesthroughput genetic screening3 dio geneshuman obesity loci3 geneshuman obesityrnai screeninginvertebrate modelprevent diodio ).several genesortholog genesgenes would293 genespromote obesityinduced obesityvivo study demonstratesrnai screenedphenotypic outcomeoverconsuming fructosenext challengeleading causeincreased interestidentified hundredshumans matchesheavy burdenhealthcare systemexperimentally defineelegans disease ’defining causalitycausally linkedcausality 293c also improves
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC