S1 Data -

Data for Figs 1–4, S1, S3, S5, S6 and S8–S10. Data A in S1 Data (Data description for Fig 1). dosekg: dose (mg) received per kg body weight; time: time postinfection (days); eps, eps05, eps95: median, 5th, and 95th percentile, respectively, for antiviral effect (numeric between 0 and 1); lvl, lvl05, lvl95: median, 5th, and 95th percentile, respectively, for blood viral load (log₁₀ copies/mL). Data B in S1 Data (Data description for Fig 2). dose: dose received (mg); time: time postinfection (days); cc, cc05, cc95: median, 5th, and 95th percentile, respectively, for tecovirimat plasma concentrations (ng/mL); eps, eps05, eps95: median, 5th, and 95th percentile, respectively, for antiviral effect (numeric between 0 and 1). Data C in S1 Data (Data description for Fig 3). ID: subject identity; time: time postinfection (days); incub: time of symptom onset (days postinfection); lvl: lesion viral load (log₁₀ copies/mL); cens: 0 for observed value above the limit of detection (2.9 log₁₀ copies/mL), 1 otherwise; TTP: time to viral peak (days postinfection); diff: delay between viral peak and symptom onset (days). Data D in S1 Data (Data description for Fig 4). initday: time of treatment initiation; dose: dose received; maxvl05, maxvl50, maxvl95: 5th, 50th, and 95th percentile, respectively, for peak viral load (log₁₀ copies/mL); TTP05, TTP50, TTP95: 5th, 50th, and 95th percentile, respectively, for time to viral peak (days postinfection); lloq2.9q05, lloq2.9q50, lloq2.9q95: 5th, 50th, and 95th percentile, respectively, for time to undetectable virus by qPCR (days postinfection); lloq6.5q05, lloq6.5q50, lloq6.5q95: 5th, 50th, and 95th percentile, respectively, for time to undetectable virus by viral culture (days postinfection); dur6.5q05, dur6.5q50, dur6.5q95: 5th, 50th, and 95th percentile, respectively, for duration of positive viral culture (days). Data E in S1 Data (Data description for S1 Fig). ID: animal identity; time: time postinfection (days); lvl: blood viral load (log₁₀ copies/mL); cens: 0 for observed value above the limit of detection, 1 otherwise; dosekg: dose (mg) received per kg body weight; eps: predicted antiviral effect (numeric between 0 and 1). Data F in S1 Data (Data description for S3 Fig). ID: animal identity; pkday: dosing day; timedose: time since last dose (hour); conc: tecovirimat plasma concentration (ng/mL); type: fit for model prediction, obs for observed concentration; dosekg: dose (mg) received per kg body weight. Data G in S1 Data (Data description for S5 Fig). weight: body weight (kg); time: time postinfection (days); cc, cc05, cc95: 5th, 50th, and 95th percentile, respectively, for tecovirimat plasma concentrations (ng/mL); eps, eps05, eps95: 5th, 50th, and 95th percentile, respectively, for antiviral effect (numeric between 0 and 1). Data H in S1 Data (Data description for S6 Fig). ID: subject identity; time: time postinfection; lvl: lesion viral load (log₁₀ copies/mL); cens: 1 if simulated value below the limit of detection (2.9 log₁₀ copies/mL), 0 if observed data; empirical_median, empirical_lower, empirical_upper: 50th, 5th, and 95th percentile, respectively, for empirical data (log₁₀ copies/mL); theoretical_median_median, theoretical_median_piLower, theoretical_median_piUpper: 50th, 5th, and 95th percentile, respectively, for predicted median (log₁₀ copies/mL); theoretical_lower_median, theoretical_lower_piLower, theoretical_lower_piUpper: 50th, 5th, and 95th percentile, respectively, for predicted 5th percentile (log₁₀ copies/mL); theoretical_upper_median, theoretical_upper_piLower, theoretical_upper_piUpper: 50th, 5th, and 95th percentile, respectively, for predicted 95th percentile (log₁₀ copies/mL). Data I in S1 Data (Data description for S8 Fig). time: time postinfection; dose: dose received; rate2.9, rate2.9q05, rate2.9q95: 50th, 5th, and 95th percentile, respectively, for the percentage of detectable virus by qPCR; rate6.5, rate6.5q05, rate6.5q95: 50th, 5th, and 95th percentile, respectively, for the percentage of detectable virus by viral culture; Data J in S1 Data (Data description for S9 Fig). dose: dose received; maxvl05, maxvl50, maxvl95: 5th, 50th, and 95th percentile, respectively, for peak viral load (log₁₀ copies/mL); TTP05, TTP50, TTP95: 5th, 50th, and 95th percentile, respectively, for time to viral peak (days postinfection); lloq2.9q05, lloq2.9q50, lloq2.9q95: 5th, 50th, and 95th percentile, respectively, for time to undetectable virus by qPCR (days postinfection); lloq6.5q05, lloq6.5q50, lloq6.5q95: 5th, 50th, and 95th percentile, respectively, for time to undetectable virus by viral culture (days postinfection); dur6.5q05, dur6.5q50, dur6.5q95: 5th, 50th, and 95th percentile, respectively, for duration of positive viral culture (days). EC50x: EC₅₀ fixed value for simulation compared to the final estimate (times). Data K in S1 Data (Data description for S10 Fig). dose: dose received; maxvl05, maxvl50, maxvl95: 5th, 50th, and 95th percentile, respectively, for peak viral load (log₁₀ copies/mL); TTP05, TTP50, TTP95: 5th, 50th, and 95th percentile, respectively, for time to viral peak (days postinfection); lloq2.9q05, lloq2.9q50, lloq2.9q95: 5th, 50th, and 95th percentile, respectively, for time to undetectable virus by qPCR (days postinfection); lloq6.5q05, lloq6.5q50, lloq6.5q95: 5th, 50th, and 95th percentile, respectively, for time to undetectable virus by viral culture (days postinfection); dur6.5q05, dur6.5q50, dur6.5q95: 5th, 50th, and 95th percentile, respectively, for duration of positive viral culture (days). h: h fixed value for simulation.

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