Proteome database of Salmonella typhimurium strain LT2

Salmonella typhimurium is a Gram-negative, enteric pathogen capable of causing serious illness in humans. An intracellular pathogen, S. typhimurium originally evolved from Escherichia coli, and the reasons the divergence in speciation took place remains mysterious considering that both species share dramatically different lifestyles. S. typhimurium is motile through the presence of peritrichous flagella on the cell surface. Of greater importance is that S. typhimurium is capable of adopting different metabolic modes through its facultative anaerobic metabolic capability which endows the bacterium to survive under both aerobic and anaerobic environments. This work sought to provide fundamental information about the proteome of S. typhimurium strain LT2 by parsing its annotated proteome file downloaded from UniProt through an in-house MATLAB proteome analysis software. Comprising protein name, amino acid sequence, and calculated variables such as number of residues, molecular weight and nucleotide sequence, the proteome database of S. typhimurium should provide a useful resource for further investigation into mysteries concerning the pathogenic mechanisms of this bacterium.