PhenoAgeAccel GWAS summary statistics

The association between accelerated PhenoAge with each SNP was examined using an efficient Bayesian linear mixed effects model (BOLT-LMM software version 2.2) for the outcome of PhenoAge with additive allelic effect of the candidate SNP, and other fixed effects: chronological age (to make the case of accelerated biological age), sex, genotyping array type, and assessment center, plus random polygenic and environment effects. By default, the LD scores included in the BOLT-LMM for European-ancestry samples were used to calibrate the BOLT-LMM statistic.

N=107,460

SNP: rs number or ID string

CHR: chromosome

BP: physical (base pair) position

GENPOS: genetic position either from bim file or interpolated from genetic map

ALLELE1: first allele in bim file (usually the minor allele), used as the effect allele

ALLELE0: second allele in bim file, used as the reference allele

A1FREQ: frequency of first allele

F_MISS: fraction of individuals with missing genotype at this SNP

BETA: effect size from BOLT-LMM approximation to infinitesimal mixed model

SE: standard error of effect size

P_BOLT_LMM_INF: infinitesimal mixed model association test p-value

P_BOLT_LMM: non-infinitesimal mixed model association test p-value