Despite the vast scientific evidence obtained from the genomic sequencing of COVID-19, a controversy regarding its origin has been created in the mass media. This could potentially have a long-term influence on the behavior among individuals, such as failure to comply with proposed social distancing measures, leading to a consequent rise in the morbidity and mortality rates from COVID-19 infection. Several studies have collected information about knowledge, attitudes and practices regarding COVID-19; however, very little is known about the relationship of the perceptions of the individuals regarding the origin of the virus with the knowledge and perception about social distancing. This study aimed at ascertaining this relationship. For such purpose, a web-based cross-sectional study was conducted among a sample population from five provinces of the Dominican Republic within the period of June to July of 2020. The data collection instrument exploited in the study was a self-designed questionnaire distributed throughout different social media platforms. A purposive sampling strategy was implemented and a total of 1195 respondents completed the questionnaire. The collected data was analyzed using SPSS. Descriptive statistics, stepwise multiple linear regression and one-way multivariate analysis were implemented to test the hypotheses. The level of education was significantly associated (P = .0.017) with individuals’ perception about the origin of COVID-19, whilst only age (P = .032) and education level (P < .001) statistically significantly predicted ‘knowledge about social distancing’. Perception of COVID-19 origin was statistically significant associated (P = <.001) with the measures of the dependent variables (knowledge and perception on social distancing). The present study has established a possible link between the ‘perception of COVID-19 origin’ and ‘the perception and knowledge about social distancing’.