Table 3.xls (5.5 kB)
Percentage growth of M. mycetomatis at 100 μM and 25 μM, IC50 and MIC50 values, Galleria mellonella larvae survival and in vivo significance of the eight benzimidazole carbamates from the Pathogen Box, Stasis Box and Pandemic Response Box tested against Madurella mycetomatis.
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posted on 2022-02-04, 18:36 authored by Wilson Lim, Bertrand Nyuykonge, Kimberly Eadie, Mickey Konings, Juli Smeets, Ahmed Fahal, Alexandro Bonifaz, Matthew Todd, Benjamin Perry, Kirandeep Samby, Jeremy Burrows, Annelies Verbon, Wendy van de SandePercentage growth of M. mycetomatis at 100 μM and 25 μM, IC50 and MIC50 values, Galleria mellonella larvae survival and in vivo significance of the eight benzimidazole carbamates from the Pathogen Box, Stasis Box and Pandemic Response Box tested against Madurella mycetomatis.
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pandemic response boxminimal inhibitory concentrationsmedicinal chemistry optimisationfungal orders sordarialesaminoquinolone derivative tafenoquinemadurella tropicana madurella pseudomycetomatis galleria mellonella find novel drugsfalciformispora senegalensis div >< pseven inhibited growthpromising drug candidatesmadurella mycetomatis benzimidazole carbamates fenbendazoleeumycetoma promising candidatesmycetomatis vivo vitro novel antifungalstreat eumycetomasignificantly prolongmycetos ).medicopsis romeroilike moleculeslarvae survivalfour compoundsfive speciescure ratescompounds activealso serve26 compounds
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