PAD meta-analysis van Zuydam et al. 2020

There are 6 files that include summary statistics from the analysis of PAD:

1. pad_primary.txt.gz

2. pad_diabetes.txt.gz

3. pad_nodiabetes.txt.gz

4. pad_diabetesvsnodiabetes.txt.gz

5. pad_neversmoker.txt.gz

6. pad_eversmoker.txt.gz

7. pad_eversmokervsneversmoker.txt.gz

Each file contains the following columns:

1) "chr" - Chromosome

2) "bp" - base pair position

3) "or_allele" - the allele which the odds ratio refers to

4) "nonor_allele" - the other allele

5) "snp" - refsnp id

6) "eaf" - effect allele frequency of the or allele

7) "or" - odds ratio

8) "or_se" - standard error of the odds ratio

9) "p" - p value of significance

10) "ncases" - number of cases

11) "ncontrols" - number of controls

The ever smoker vs never smoker / diabetes vs no diabetes files contain extra columns:

12) "pint" - the interaction p value for differences in odds ratios between strata

13) "NEFF" - effective sample size. In the final meta-analyses NEFF>=4000 was used to filter variants. For the interaction summary statistics we included the variant in both strata even if it only passed QC in one. N.B. treat variants with NEFF<4000 with caution.

Any issues with these summary statistics please contact nvanzuydam@gmail.com