pone.0268067.s002.xlsx (288.16 kB)
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posted on 2022-05-19, 17:47 authored by Kenichi Kaneko, Ryosuke Miyasaka, Roslyn HaymanData underlying our results in this manuscript.
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ussing chamber mountedtransepithelial electrical resistanceteer ), indicatingsmall intestine occursgel filtration chromatographycoating poorly water4 times highertight junction penetrationwithout significant changesingle oral doseblood concentration timeuntreated az groupsignificantly higher permeabilityussing chamber studydiv >< pwithout peyer ’hap formulation grouphap formulation ),ex vivo tested az bioavailabilityvia tight junctionstight junctionspeyer ’hap formulationvivo significant differenceoral administrationhigh concentrationhap ’az permeabilityvitro drug permeabilityhap particlessoluble drugsresults suggestpatch tissueintracellular transportintestinal villiintestinal tractintestinal epitheliumimproves bioavailabilityearlier reportedbinding stateadministered orally?
