Metadata record for the manuscript: Targeting the Epichaperome As an Effective Precision Medicine Approach in a Novel PML-SYK Fusion Acute Myeloid Leukemia
Summary
This metadata record provides details of the data supporting the claims of the related manuscript: “Targeting the Epichaperome As an Effective Precision Medicine Approach in a Novel PML-SYK Fusion Acute Myeloid Leukemia ”.
The related study aimed to prospectively identify patients likely to respond to epichaperome inhibitors to measure target engagement and dependency during treatment by developing a flow cytometry-based assay for evaluation and monitoring of epichaperome abundance at the single-cell level.
Subject of data: leukaemia cells from a patient with an unclassified myeloproliferative neoplasm harbouring a novel PML-SYK fusion that transformed to AML
Sample size: case report containing data from a single patient
Data access
All
data are shared openly. The RNA sequencing and whole exome sequencing data are
shared in the European Genotype-phenotype
Archive under accession https://identifiers.org/ega.study:EGAS00001004992. All other data are shared as part of this figshare
metadata record. A list of which datafiles underlie which figures in the
manuscript is also included in Excel .xlsx format in the file ‘sugita_datafiles_underlying_figures_lookup.xlsx’.
Corresponding authors
Monica L. Guzman, Ph.D., Weill Cornell Medicine, 1300 York Ave, C-610C, Box 113, New York, NY 10065. Email: mlg2007@med.cornell.edu
Juan Miguel Mosquera, M.D, M.Sc., Weill Cornell Medicine, 1300 York Ave, Box 69, New York, NY 10065. Email: jmm9018@med.cornell.edu
Name of Institutional Review Board or ethics
committee that approved the study
